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etravirine will lessen the extent or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers cuts down plasma focus of abemaciclib and its metabolites.Abemaciclib targets CDK4 and CDK6, proteins that aid regulate cell division. C